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Myricetin- prevents obesity and insulin resistance

Myricetin is a dietary flavonoid that is abundant in plants such as berries, tea, fruits, wines and vegetables. Myricetin has various biological functions including antioxidant, cytoprotective, antiviral, antimicrobial, anti-inflammatory, and antiplatelet activities. And it is a useful substance.


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According to research, myricetin stimulates glucose transport in rat adipocytes and enhances insulin-stimulated lipogenesis. Moreover, myricetin treatment ameliorates hyperglycemia in diabetic rat, and normalizes the carbohydrate metabolic products and renal function markers in streptozotocin and cadmium-induced diabetic nephrotoxic rats.


Myricetin prevents body weight gain

Brown adipose tissue (BAT), is the main source of non-trembling heat in mammals, plays an important role in maintaining animal body temperature and energy balance, especially for young mammals. It makes the energy of glucose and fatty acid decomposition can not be converted into ATP (for the body directly to the energy of the material), but can only be converted into heat.

In the present study, it was revealed that myricetin activated BAT in db/db mice. Consequently, myricetin protected against body weight gain without change of diet consumption and improved IR, glucose tolerance and hepatic steat-osis in db/db mice.

  

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Myricetin increases BAT activity and thermogenesis of db/db mice. Yellow dashed triangle represented the anatomical site of interscapular BAT.  Representative infrared thermal image after cold exposure.


The prevalence of obesity is associated with adverse health outcomes such as type 2 diabetes, fatty liver disease, stroke, cardiovascular diseases, and certain types of cancer. The pharmacological approaches to the treatment of obesity have been focused on reducing food absorption and/or depressing appetite.

To investigate whether myricetin prevents body weight gain, male db/db mice at 4 weeks of age were orally treated with vehicle or myricetin for 14 weeks. Myricetin-treated db/db mice did not gain as much body weight as control mice.


 

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According to the experimental data and charts, it can be concluded that myricetin can prevent body weight gain and can be a limited choice for people to lose weight.


Myricetin prevents insulin resistance (IR)

Insulin resistance refers to a variety of causes of insulin to promote glucose uptake and utilization of the efficiency of the body compensatory secretion of excessive insulin to produce hyperinsulinemia, in order to maintain blood sugar stability. Insulin resistance easily leads to metabolic syndrome and type 2 diabetes.

Recently, it has been reported that myricetin improves IR in diet- induced obese mouse by diminishing the level of serum inflammatory cytokines. Db/db mice developed obesity-induced hyperlipidemia, fatty liver and IR were tested. Therefore, it was tested whether myricetin- mediated fat reduction prevented IR and liver steatosis in db/db mice. 


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The results from GTT showed that plasma glucose level at 15, 60 and 90 min after glucose injection and the value of area under the curve (AUC) were significantly decreased in myricetin-treated mice than in control mice (Fig. A, B). ITT and AUC further supported the significant improvement of insulin sensitivity after myricetin treatment (Fig. C, D).


Taken together, these results demonstrate that myricetin prevents IR, attenuates hepatic steatosis and improves lipid.


Collectively, the results in this study show that myricetin prevents obesity and systemic IR in db/db mice by activating BAT, recruiting beige cells and increasing adiponectin secretion in BAT. After continuous research on myricetin, you can get a new type of insulin resistance drugs and weight loss drugs



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