Cardiac hypertrophy is the myocardial response to various pathological heart diseases, including hypertension, myocardial ischemia, valve disease, and heart failure. Cardiac hypertrophy is characterized by an enhanced protein synthesis, increase in cell size, and heightened organization of the sarcomere. Sustained pathological hypertrophy leads to cardiac remodeling, which is associated with increased interstitial fibrosis and impaired cardiac function.
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