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Glycyrrhizic Acid

What is Glycyrrhizic acid


Glycyrrhizic acid(or glycyrrhizin) is the main sweet ingredient of licorice roots.It is structurally a saponin that has been used as an emulsifier and gel forming agent in food and cosmetics. Its aglycone is enoxolone and it has therefore been used as a prodrug for that compound, for example it is used in Japan to prevent liver carcinogenesis in patients with chronic hepatitis C.In addition,it has potential immunomodulating, anti-inflammatory, hepato-protective and neuro-protective.


Glycyrrhizic acid regulates certain enzymes involved in inflammation and oxidative stress, and downregulates certain pro-inflammatory mediators to prevent inflammation and reactive oxygen species (ROS)-induced damage.


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Health Benefits of taking Glycyrrhizic acid


Anti-allergic

Active systemic allergic reaction in Balb/c mice suggested that GA can inhibit the increased level of IL-4 in a dose-dependent manner and restore the immune balance of TH1/TH2 cells.In addition, GA significantly attenuated B cells that produced allergen-specific IgE and IgG1, in part because of low levels of TH2 cytokines.Passive skin allergy in vivo and RBL-2H3 cell immunology tests in vitro showed that GA play a role of "mast cell stabilizer",as it inhibited mast cell threshing and reduce vascular permeability by inhibiting the expression of Orai1, STIM1 and TRPC1, which blocked extracellular Ca2+ influxes.These three studies in vivo and in vitro have shown that GA can be used as an effective anti-allergic agent from food for the prevention and treatment of IgE-mediated allergic reactions.


Heal Gut Inflammation and Ulcers

Glycyrrhizic acid is a good adjunctive treatment to standard clarithromycin triple therapy in the treatment of Helicobacter pylori as it increases the eradication rate of H. pylori by about 20% .In patients with dyspepsia, licorice helped symptoms of nausea, indigestion, and stomach pains .In rats with stomach ulcers caused by aspirin, licorice decreased the number and size of the ulcers.

 

Antioxidant

Fluorescence method shows that glycyrrhizic acid cleared three kinds of reactive oxygen species: hydrogen peroxide, peroxy radicals and superoxide anions. However, glycyrrhizic acid is unable to remove peroxynitrite, hydroxyl radicals, singlet oxygen and 2,2-diphenyl-1-bitteryl hydrazine (DPPH) groups, indicating that glycyrrhizic aicd is a weak scavenger.


Help with Infections

Glycyrrhizic acid stimulates the immune system and has antioxidant properties .And it has antiviral, antibacterial, and anti-fungal properties.In a cell-based study, glycyrrhizic acid (from licorice extract) was effective in controlling the growth of bacteria.

 

Dosage

There are two kinds of licorice, "standard" licorice and " de-glycyrrhizinated " licorice (DGL). Each type applies to different conditions.Standard licorice containing licorice is used in respiratory infections, chronic fatigue syndrome or herpes.Licorice root in capsules, 5-6 grams per day, can be used.250 to 500 mg of concentrated extract per day is another option.Alternatively, tea can be made by boiling 1/2 ounce (14 grams) for 15 minutes in 1 pint (500ml) of water and then drinking two to three cups (500 to 750 milliliters) per day.Long-term use (more than 2 to 3 weeks) high content (more than 10 g / day) containing glycyrrhizic acid products should be attempted only under the supervision of a doctor.Licorice cream or gel can be applied three to four times a day directly to herpes.


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